What are the most reliable airlines from Detroit Metropolitan Wayne County Airport to San Francisco?

No one likes to see their flight delayed. When booking a flight from Detroit Metropolitan Wayne County Airport to San Francisco consider choosing China Southern (100%), ITA Airways (93%) or KLM (92%) as they are the most reliable in getting you off to your destination on time.

What are the most popular airlines that fly from Detroit Metropolitan Wayne County Airport to San Francisco?

The most popular airlines flying from Detroit Metropolitan Wayne County Airport to San Francisco are American Airlines, JetBlue and Delta. Something to consider prior to booking your flight.

What is the cheapest day to fly round-trip from Detroit Metropolitan Wayne County Airport to San Francisco?

Users have found that flying from Detroit Metropolitan Wayne County Airport to San Francisco on a Sunday typically leans towards higher prices. However, this doesn’t mean you still can’t find a deal. Flexibility with other aspects of your flight can still land a great price for your trip.

What is the cheapest month to fly from Detroit Metropolitan Wayne County Airport to San Francisco?

Flights from Detroit Metropolitan Wayne County Airport to San Francisco lean towards being more expensive in January. Prices are generally better when you fly from Detroit Metropolitan Wayne County Airport to San Francisco in May, with the cheapest ticket starting at $205.

What airports do I use to fly from Detroit to San Francisco?

If you book a flight from Detroit to San Francisco, you will be flying from Detroit Metropolitan Wayne County to San Francisco. Flights to San Francisco (SFO) from Detroit Metropolitan Wayne County (DTW) take 5h 02m for a nonstop flight. There are 12 flights from Detroit Metropolitan Wayne County to San Francisco per day from 8 airlines.

Can I find deals for flights from Detroit to San Francisco that include hotel bookings?

Yes. In addition to deals on Detroit to San Francisco flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from Detroit to San Francisco?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Detroit to San Francisco.

Can I find deals for business class flights from Detroit to San Francisco?

Yes. Cheapflights offers flight deals from Detroit to San Francisco by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$139+ Flights from Detroit Metropolitan Wayne County Airport to San Francisco

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Cheapflights Tip: The best prices from Detroit Metropolitan Wayne County to San Francisco are usually found in June or May, booked 32 days in advance, depart on a Thursday or Friday and return on a Wednesday

Cheap flight deals from Detroit to San Francisco

Round-trip from	$275 (FlightHub)
One-way from	$139 (Kiwi.com)
Popular in	January
Cheapest in	June
Average price	$406
Good round-trip deal	$392 or less
Good one-way deal	$300 or less

From Detroit Metropolitan Wayne County to San Francisco

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One-way flight from Detroit Metropolitan Wayne County to San Francisco

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Highest demand for flights based on searches. 18% potential increase in price ($119 potential increase over avg. RT price).

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Cheapest flight prices on average. 3% potential price decrease ($18 potential savings vs. average RT price).

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Average for round-trip flights in June 2025

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Price to beat on a round-trip flight from Detroit Metropolitan Wayne County to San Francisco.

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Price to beat on a one-way flight from Detroit Metropolitan Wayne County to San Francisco.

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Find flight deals from Detroit to San Francisco

Cheapest flights from Detroit to San Francisco
Explore the most affordable flight options available from Detroit to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 13, 2025.

Fri 8/18:30 amDTW - SFO

1 stop28h 05mFrontier

Mon 8/45:45 amSFO - DTW

1 stop6h 43mFrontier

Deal found 6/13

$275

Fri 9/512:16 pmDTW - SFO

1 stop11h 43mJetBlue

Fri 9/128:25 pmSFO - DTW

1 stop10h 33mJetBlue

Deal found 6/12

$276

Wed 8/209:42 amDTW - SFO

1 stop12h 11mAmerican Airlines

Sun 8/2412:45 amSFO - DTW

1 stop7h 06mAmerican Airlines

Deal found 6/12

$281

Fri 7/117:43 pmDTW - SFO

Nonstop5h 07mUnited Airlines

Sun 7/139:30 pmSFO - DTW

Nonstop4h 40mUnited Airlines

Deal found 6/12

$289

Wed 9/37:10 amDTW - SFO

2 stops10h 30mSouthwest

Thu 9/118:35 amSFO - DTW

1 stop6h 30mSouthwest

Deal found 6/13

$302

Thu 6/268:25 pmDTW - SFO

Nonstop5h 08mDelta

Sat 7/1211:40 pmSFO - DTW

Nonstop4h 28mDelta

Deal found 6/11

$319

Thu 6/267:00 pmDTW - SFO

1 stop6h 53mSun Country Air

Thu 8/711:59 pmSFO - DTW

1 stop15h 12mSun Country Air

Deal found 6/12

$335

Best flights from Detroit to San Francisco
Discover carefully curated flight deals from Detroit to San Francisco that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated June 13, 2025.

Fri 8/18:30 amDTW - SFO

1 stop28h 05mFrontier

Mon 8/45:45 amSFO - DTW

1 stop6h 43mFrontier

Deal found 6/13

$275

Fri 9/512:16 pmDTW - SFO

1 stop11h 43mJetBlue

Sat 9/138:40 pmSFO - DTW

1 stop11h 50mJetBlue

Deal found 6/12

$276

Wed 8/209:42 amDTW - SFO

1 stop12h 11mAmerican Airlines

Sun 8/2412:45 amSFO - DTW

1 stop7h 06mAmerican Airlines

Deal found 6/12

$281

Fri 7/117:43 pmDTW - SFO

Nonstop5h 07mUnited Airlines

Sun 7/139:30 pmSFO - DTW

Nonstop4h 40mUnited Airlines

Deal found 6/12

$289

Wed 9/37:10 amDTW - SFO

2 stops10h 30mSouthwest

Thu 9/118:35 amSFO - DTW

1 stop6h 30mSouthwest

Deal found 6/13

$302

Thu 6/268:25 pmDTW - SFO

Nonstop5h 08mDelta

Sat 7/1211:40 pmSFO - DTW

Nonstop4h 28mDelta

Deal found 6/11

$319

Thu 6/267:00 pmDTW - SFO

1 stop6h 53mSun Country Air

Thu 8/711:59 pmSFO - DTW

1 stop15h 12mSun Country Air

Deal found 6/12

$335

Last-minute flights from Detroit to San Francisco
Discover last-minute flight deals from Detroit to San Francisco. Data last updated June 13, 2025 and is based on user searches.

Fri 6/208:30 amDTW - SFO

1 stop28h 12mFrontier

Sat 6/218:31 pmSFO - DTW

1 stop7h 25mFrontier

Deal found 6/11

$294

Fri 6/2011:27 amDTW - SFO

1 stop14h 26mSun Country Air

Sun 6/2211:59 pmSFO - DTW

1 stop15h 12mSun Country Air

Deal found 6/12

$340

Fri 6/208:25 pmDTW - SFO

Nonstop5h 08mDelta

Fri 7/1110:40 pmSFO - DTW

Nonstop4h 31mDelta

Deal found 6/11

$379

Sat 6/213:10 pmDTW - SFO

2 stops11h 00mSouthwest

Tue 6/245:25 amSFO - DTW

2 stops8h 25mSouthwest

Deal found 6/12

$499

Sat 6/215:10 pmDTW - SFO

1 stop7h 56mAlaska Airlines

Sat 8/167:49 pmSFO - DTW

2 stops10h 23mAlaska Airlines

Deal found 6/11

$791

Mon 6/237:07 pmDTW - SFO

1 stop19h 01mMultiple Airlines

Sun 6/2911:59 pmSFO - DTW

2 stops28h 31mMultiple Airlines

Deal found 6/10

$449

Mon 6/237:43 pmDTW - SFO

Nonstop5h 07mUnited Airlines

Sun 6/299:15 pmSFO - DTW

1 stop8h 33mUnited Airlines

Deal found 6/12

$474

Wed 6/258:30 amDTW - SFO

1 stop28h 12mFrontier

Wed 7/91:09 pmSFO - DTW

1 stop23h 19mFrontier

Deal found 6/11

$275

Wed 6/256:24 pmDTW - SFO

3 stops31h 29mMultiple Airlines

Sun 6/2911:59 pmSFO - DTW

2 stops28h 31mMultiple Airlines

Deal found 6/10

$451

Thu 6/268:25 pmDTW - SFO

Nonstop5h 08mDelta

Sat 7/1211:40 pmSFO - DTW

Nonstop4h 28mDelta

Deal found 6/11

$319

Thu 6/267:00 pmDTW - SFO

1 stop6h 53mSun Country Air

Sun 8/311:59 pmSFO - DTW

1 stop7h 32mSun Country Air

Deal found 6/12

$335

Tue 7/17:30 amDTW - SFO

1 stop9h 32mJetBlue

Wed 7/911:14 amSFO - DTW

1 stop9h 45mJetBlue

Deal found 6/12

$338

One-way flights from Detroit to San Francisco
Search for one-way flight options from Detroit to San Francisco. Find affordable one-way fares based on user searches. Data last updated June 13, 2025.

Fri 9/129:38 amDTW - SFO

1 stop14h 45mFrontier

Deal found 6/10

$139

Sat 9/1312:16 pmDTW - SFO

1 stop11h 43mJetBlue

Deal found 6/12

$140

Tue 7/156:45 amDTW - SFO

1 stop15h 59mMultiple Airlines

Deal found 6/12

$141

Thu 8/76:21 pmDTW - SFO

1 stop7h 35mSun Country Air

Deal found 6/11

$143

Tue 8/58:10 amDTW - SFO

1 stop9h 30mSouthwest

Deal found 6/12

$149

Fri 9/124:51 pmDTW - SFO

1 stop10h 08mHawaiian Airlines

Deal found 6/11

$154

Fri 7/410:02 amDTW - SFO

1 stop12h 41mAmerican Airlines

Deal found 6/12

$179

Mon 9/296:30 amDTW - SFO

2 stops13h 27mAlaska Airlines

Deal found 6/11

$217

Tue 8/127:05 amDTW - SFO

2 stops14h 47mDelta

Deal found 6/12

$259

Wed 7/26:00 amDTW - SFO

1 stop21h 30mUnited Airlines

Deal found 6/11

$263

Cheapflights Fare Finder

Use the filters below to find and compare flights from Detroit Metropolitan Wayne County Airport to San Francisco that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

DetroitSan Francisco

DTW - SFO

DTWSFO

Detroit Metropolitan Wayne County

Fri 8/1

8:30 am-9:35 am

1 stop28h 05m

San Francisco

Mon 8/4

5:45 am-3:28 pm

1 stop6h 43m

$275

DetroitSan Francisco

DTW - SFO

DTWSFO

Detroit Metropolitan Wayne County

Fri 9/5

12:16 pm-8:59 pm

1 stop11h 43m

San Francisco

Sat 9/13

8:40 pm-11:30 am

1 stop11h 50m

$276

DetroitSan Francisco

DTW - SFO

DTWSFO

Detroit Metropolitan Wayne County

Wed 8/20

9:42 am-6:53 pm

1 stop12h 11m

San Francisco

Sun 8/24

12:45 am-10:51 am

1 stop7h 06m

$281

DetroitSan Francisco

DTW - SFO

DTWSFO

Detroit Metropolitan Wayne County

Fri 7/11

7:43 pm-9:50 pm

Nonstop5h 07m

San Francisco

Sun 7/13

9:30 pm-5:10 am

Nonstop4h 40m

$289

DetroitSan Francisco

DTW - SFO

DTWSFO

Detroit Metropolitan Wayne County

Wed 9/3

7:10 am-2:40 pm

2 stops10h 30m

San Francisco

Thu 9/11

8:35 am-6:05 pm

1 stop6h 30m

$302

DetroitSan Francisco

DTW - SFO

DTWSFO

Detroit Metropolitan Wayne County

Thu 6/26

8:25 pm-10:33 pm

Nonstop5h 08m

San Francisco

Fri 7/11

10:40 pm-6:11 am

Nonstop4h 31m

$319

DetroitSan Francisco

DTW - SFO

DTWSFO

Detroit Metropolitan Wayne County

Thu 6/26

7:00 pm-10:53 pm

1 stop6h 53m

San Francisco

Thu 8/7

11:59 pm-6:11 pm

1 stop15h 12m

$335

DetroitSan Francisco

DTW - SFO

DTWSFO

Detroit Metropolitan Wayne County

Fri 9/12

9:38 am-9:23 pm

1 stop14h 45m

$139

DetroitSan Francisco

DTW - SFO

DTWSFO

Detroit Metropolitan Wayne County

Sat 9/13

12:16 pm-8:59 pm

1 stop11h 43m

$140

DetroitSan Francisco

DTW - SFO

DTWSFO

Detroit Metropolitan Wayne County

Tue 7/15

6:45 am-7:44 pm

1 stop15h 59m

$141

Flights are sorted by cheapest round-trip flights first.

Deals found on 6/10

Showing 1-10 of 17 results

The best insider tips for Detroit Metropolitan Wayne County Airport to San Francisco flights

Cheapflights partnered with top experts to bring you the best recommendations for your Detroit Metropolitan Wayne County Airport to San Francisco trip

Airports

DTW

At DTW, security lines are typically short, with waits under 10 minutes at McNamara Terminal.

SFO

For a budget-friendly arrival, take BART from SFO to downtown San Francisco in about 40 minutes.

Our travel experts

Brandon Schultz

Expert on DTW

Harriet Baskas

Expert on SFO

Best time to book a flight from Detroit to San Francisco

Have a flexible travel schedule? Discover the best time to fly to San Francisco from Detroit with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Detroit Metropolitan Wayne County Airport to San Francisco

How far ahead should I book a flight from Detroit Metropolitan Wayne County Airport to San Francisco?

The price you pay for your flight from Detroit Metropolitan Wayne County Airport to San Francisco may vary depending on when you book. For the best chance of a lower fare, look to book 32 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.

What is the cheapest month to book a flight from Detroit Metropolitan Wayne County Airport to San Francisco?

Currently, January is the cheapest month in which you can book a flight from Detroit Metropolitan Wayne County Airport to San Francisco (average of $276). Flying from Detroit Metropolitan Wayne County Airport to San Francisco in June is currently the most expensive (average of $364). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from DTW to SFO?

When flying from Detroit Metropolitan Wayne County Airport to San Francisco, the time of day you fly usually plays a role in the price. Save by searching for a flight at noon, which can drop the price by up to 20% versus a flight in the evening.

What is the cheapest day to fly from Detroit Metropolitan Wayne County Airport to San Francisco?

Travelers seeking maximum savings on their Detroit Metropolitan Wayne County Airport to San Francisco flight should consider departing on Wednesday afternoons when fares are most often at their lowest. Monday evenings flights should be avoided if possible as fares are typically the most expensive at this time.

Weekly flight availability from Detroit Metropolitan Wayne County Airport to San Francisco

The most flights from DTW to SFO are scheduled on a Thursday (18 on average). You will have fewer flight options on Saturday, which is when the least amount of flights are scheduled (4 on average).

Rainfall in San Francisco by month

In terms of precipitation, rainfall in San Francisco ranges from 0.0 - 4.4 inches per month. January is typically the wettest month, when rainfall can reach 4.4 in. July is typically the driest time to visit San Francisco when rainfall is around 0.0 in.

Temperature in San Francisco by month

If weather is an important factor for your trip to San Francisco, use this chart to help with planning. For those seeking warmer temperatures, September is the ideal time of year to visit, when temperatures reach an average of 62.6 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 51.8 F).

Reviews of airlines servicing San Francisco

Peruse reviews from past customers who have flown with Alaska Airlines, Southwest and Delta from Detroit to San Francisco to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.

Alaska Airlines

8.0

Very good

10,000 reviews

Reviews

1 / 20

10.0

Excellent

James,Apr 2025

LAX - SFO

Good flight except the uncontrollable cold air from the ceiling.

Alaska Airlines

8.0

Very good

10,000 reviews

Alaska Airlines

8.0

Very good

10,000 reviews

Reviews

1 / 20

10.0

Excellent

James,Apr 2025

LAX - SFO

Good flight except the uncontrollable cold air from the ceiling.

Southwest

8.0

Very good

4,286 reviews

Alaska Airlines

8.0

Very good

10,000 reviews

Reviews

1 / 20

10.0

Excellent

James,Apr 2025

LAX - SFO

Good flight except the uncontrollable cold air from the ceiling.

Delta

8.0

Very good

7,950 reviews

Alaska Airlines

8.0

Very good

10,000 reviews

Reviews

1 / 20

10.0

Excellent

James,Apr 2025

LAX - SFO

Good flight except the uncontrollable cold air from the ceiling.

Hawaiian Airlines

7.9

Good

2,496 reviews

Alaska Airlines

8.0

Very good

10,000 reviews

Reviews

1 / 20

10.0

Excellent

James,Apr 2025

LAX - SFO

Good flight except the uncontrollable cold air from the ceiling.

United Airlines

7.4

Good

8,791 reviews

Alaska Airlines

8.0

Very good

10,000 reviews

Reviews

1 / 20

10.0

Excellent

James,Apr 2025

LAX - SFO

Good flight except the uncontrollable cold air from the ceiling.

Related info for your journey

What airports do I use to fly from Detroit to San Francisco?
If you book a flight from Detroit to San Francisco, you will be flying from Detroit Metropolitan Wayne County to San Francisco. Flights to San Francisco (SFO) from Detroit Metropolitan Wayne County (DTW) take 5h 02m for a nonstop flight. There are 12 flights from Detroit Metropolitan Wayne County to San Francisco per day from 8 airlines.
What are the cheapest airlines flying from Detroit Metropolitan Wayne County Airport to San Francisco round-trip?
According to our current data, Frontier ($275), JetBlue ($276), and American Airlines ($281) offers the cheapest pricing from Detroit Metropolitan Wayne County Airport to San Francisco. These flights start at 49% lower than the current average price 3 months from now.
What are the cheapest airlines to fly from Detroit Metropolitan Wayne County Airport to San Francisco one-way?
One-way options have recently been found by users for as low as $139 on Frontier. Other airlines that offer cheap prices include JetBlue from $140 and Sun Country Air from $143 one-way.
What are the most reliable airlines from Detroit Metropolitan Wayne County Airport to San Francisco?
No one likes to see their flight delayed. When booking a flight from Detroit Metropolitan Wayne County Airport to San Francisco consider choosing China Southern (100%), ITA Airways (93%) or KLM (92%) as they are the most reliable in getting you off to your destination on time.
What are the cheapest flights from Detroit Metropolitan Wayne County Airport to San Francisco?
Looking for the cheapest flight from Detroit Metropolitan Wayne County Airport to San Francisco? While on average our users pay $1,182, our data indicates the cheapest price to be $248. The most popular route (Detroit Metropolitan Wayne County - San Francisco), is priced around $214.
Can I find deals for flights from Detroit to San Francisco that include hotel bookings?
Yes. In addition to deals on Detroit to San Francisco flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from Detroit to San Francisco?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Detroit to San Francisco.
Can I find deals for business class flights from Detroit to San Francisco?
Yes. Cheapflights offers flight deals from Detroit to San Francisco by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from Detroit Metropolitan Wayne County Airport to San Francisco?
Currently, January is the cheapest month in which you can book a flight from Detroit Metropolitan Wayne County Airport to San Francisco (average of $276). Flying from Detroit Metropolitan Wayne County Airport to San Francisco in June is currently the most expensive (average of $364). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Top 8 airlines flying from Detroit to San Francisco

Airline	Cheapest	Average	Flexibility	On-time
Spirit Airlines	Cheapest$101	Average$284	FlexibilityNo cancel fee	On-time65%
Sun Country Air	Cheapest$128	Average$336	FlexibilityNo cancel fee	On-time83%
Frontier	Cheapest$141	Average$233	FlexibilityNo cancel fee	On-time62%
JetBlue	Cheapest$227	Average$308	FlexibilityNo cancel fee	On-time62%
United Airlines	Cheapest$289	Average$608	FlexibilityNo cancel fee	On-time69%
Delta	Cheapest$289	Average$599	FlexibilityNo cancel fee	On-timeN/A
American Airlines	Cheapest$305	Average$416	FlexibilityNo cancel fee	On-time71%
Southwest	Cheapest$338	Average$537	FlexibilityNo cancel fee	On-time63%

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$139+ Cheap flights from Detroit Metropolitan Wayne County Airport to San Francisco (DTW - SFO)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/12. Fares are subject to change and may not be available on all flights or dates of travel.

Find cheap flights from Detroit to San Francisco with Cheapflights

1. Tell us where you want to go

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3. Compare prices and book

Cheapflights Tip: The best prices from Detroit Metropolitan Wayne County to San Francisco are usually found in June or May, booked 32 days in advance, depart on a Thursday or Friday and return on a Wednesday

Cheap flight deals from Detroit to San Francisco

Round-trip from

One-way from

Popular in

Cheapest in

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Good round-trip deal

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Find flight deals from Detroit to San Francisco

Cheapest flights from Detroit to San FranciscoExplore the most affordable flight options available from Detroit to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 13, 2025.

Explore the most affordable flight options available from Detroit to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 13, 2025.

Cheapflights Fare Finder

Use the filters below to find and compare flights from Detroit Metropolitan Wayne County Airport to San Francisco that are best for you.

The best insider tips for Detroit Metropolitan Wayne County Airport to San Francisco flights

Cheapflights partnered with top experts to bring you the best recommendations for your Detroit Metropolitan Wayne County Airport to San Francisco trip

Airports

DTW

SFO

Our travel experts

Best time to book a flight from Detroit to San Francisco

Have a flexible travel schedule? Discover the best time to fly to San Francisco from Detroit with our price prediction graph.

Cheapflights Insights

Everything you need to know about your flight from Detroit Metropolitan Wayne County Airport to San Francisco

How far ahead should I book a flight from Detroit Metropolitan Wayne County Airport to San Francisco?

Use this chart to determine the optimal time to book a round-trip flight from Detroit to San Francisco. Price data was last updated on June 9, 2025.

What is the cheapest month to book a flight from Detroit Metropolitan Wayne County Airport to San Francisco?

What is the cheapest time of day to fly from DTW to SFO?

Find hourly flight availability from Detroit to San Francisco. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated June 13, 2025.

What is the cheapest day to fly from Detroit Metropolitan Wayne County Airport to San Francisco?

Use this chart to determine the cheapest time to fly round-trip from Detroit to San Francisco. Price data was last updated on June 8, 2025.

Weekly flight availability from Detroit Metropolitan Wayne County Airport to San Francisco

Explore weekly flight availability from Detroit to San Francisco. Discover flights operating on different days of the week, giving you the flexibility to choose a travel day that best fits your plans. Compare info to find the most convenient option for your journey. Data last updated June 13, 2025.

Rainfall in San Francisco by month

Plan your trip to San Francisco by taking into account the average rainfall totals by month.

Temperature in San Francisco by month

Plan your trip to San Francisco by taking into account the average temperature totals by month.

Reviews of airlines servicing San Francisco

Peruse reviews from past customers who have flown with Alaska Airlines, Southwest and Delta from Detroit to San Francisco to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.

Related info for your journey

Find useful and relevant information for your journey from Detroit to San Francisco. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

What airports do I use to fly from Detroit to San Francisco?

What are the cheapest airlines flying from Detroit Metropolitan Wayne County Airport to San Francisco round-trip?

What are the cheapest airlines to fly from Detroit Metropolitan Wayne County Airport to San Francisco one-way?

What are the most reliable airlines from Detroit Metropolitan Wayne County Airport to San Francisco?

What are the cheapest flights from Detroit Metropolitan Wayne County Airport to San Francisco?

Can I find deals for flights from Detroit to San Francisco that include hotel bookings?

How can I find direct flights from Detroit to San Francisco?

Can I find deals for business class flights from Detroit to San Francisco?

What is the cheapest month to book a flight from Detroit Metropolitan Wayne County Airport to San Francisco?

Traveling to a place near Detroit Metropolitan Wayne County Airport?

Browse thousands of different options on Cheapflights for your next trip

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Alternative routes for Detroit to San Francisco

See prices for flight routes from nearby airports that may be better suited for you.

Top 8 airlines flying from Detroit to San Francisco

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Cheapest flights from Detroit to San Francisco
Explore the most affordable flight options available from Detroit to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 13, 2025.